Volume 14 of the ITI Treatment Guide series aims to provide a comprehensive overview on immediate implant placement and immediate loading protocols for replacement of single or multiple teeth requiring extraction. This volume outlines the current literature on immediate implant placement and immediate loading and elaborates on our understanding of the biology surrounding tooth extraction and osseointegration that underpin these treatment concepts. The importance of patient and site selection in conjunction with comprehensive treatment planning is highlighted and a risk assessment tool to aid decision making is provided. All key aspects of both the surgical and loading procedures are described in order to provide protocols that optimize the final treatment outcome. This volume also presents 9 step-by-step clinical cases performed by experts in the field, and typical complications of immediate implants are discussed, along with recommendations on how these can be prevented.